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There are currently seven drugs on the market that are angiotensin II inhibitors.
The table below shows characteristics of each of them and may be helpful for
your MD in selecting the best one for your situation.
Note: that
Candesartan improve migraines ,
and the same would be expected from Telmisartan(the other ARB that crosses the
brain barrier).
The newer ones are excluded: Eprosartan, Tasosartan and Zolarsartan.
- They increase fibrinolysis (breaks down coagulation)
- Generally CFIDS patients have low blood pressure (OI) so a BP drop is not
necessarily good.
Main Source of information:
| Chemical Name |
Losartan |
Olmesartan
|
Valsartan |
Irbesartan |
Candesartan |
Telmisartan |
Eprosartan |
| Brand Name |
Cozaar |
Benicar |
Diovan, Novartis |
Avapro,Squibb |
Antacad |
Micardis |
Teveten |
| Weight Gain Risk |
|
|
|
|
|
|
|
| Introduced |
1995 |
2002 |
|
|
|
|
|
| BP Drop |
8/5.5 |
12.5/11.5 |
7.5/4.0 |
10/6.5 |
10/6 |
9.5/6 |
7.5/4.5 |
| Affinity for the AT2 receptor |
1,000 |
12,500 |
20,000 |
8,500 |
10,000 |
3,000 |
1,000 |
| Half Life |
6-9 hrs |
13 hrs |
6 hrs |
11-15 hrs |
9 hrs |
24 hrs |
5-9 hrs |
P450 enzymes
affinity |
HIGH |
None |
None |
HIGH |
Modest |
None |
None |
| Known interactions |
ketoconazole,
troleandomycin,
cimetidine,
Rifampin |
|
|
|
|
digoxin |
|
| Crosses Blood Brain Barrier |
No |
No |
No |
No |
Yes |
Yes |
No |
| Reduces Inflammation Studies |
|
|
|
|
|
|
|
Notes:
- MRHD - Maximum Recommended Human Dose
- P450 enzymes is a factor for drug interactions.
- Reduces Inflammation often occurs in combination with other drugs. See the
citations above or see
current medline listings (there are several new studies being added every
month)
Fibrinolysis
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