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Epstein-Barr virus (EBV) is member of the human herpesvirus family and may be opportunistic re-activations with various illnesses such as CFIDS and HIV. EBV is the etiologic agent of acute infectious mononucleosis .  Most people (95% ) have EBV antibodies (meaning that they have been exposed to the infection and have overcome it), so the EBV is probably a re-activation of a past infection. Some pathogens (for example, mycoplasma) are known to reactivate past viral infections.


  • Virus is secreted intermittently in the saliva of symptomatic carriers.
  • EBV infects B lymphocytes and establishes a latent infection. The viral genome enters the nucleus and persists in an episomal form. They transform the B cell into an immortal, continuously dividing cell. A small number of these "EBV-transformed" B cells circulate in the blood of healthy carriers. Their numbers are kept in check by the host's immune response.


Symptoms include fever, generalized lymphadenopathy, sore throat, malaise, tiredness, splenomegaly, hepatomegaly, abnormal liver function tests and atypical lymphocytosis in the peripheral blood. The disease is self limiting, but convalescence may be prolonged in some cases  .


There is no official treatment for EBV. The following prescription drugs have been tried with mixed results - generally faster recover but not elimination.

  • Acyclovir, valacyclovir
  • Azcytidine
  • NFkB (transcription factor) inhibitors
  • EGFR (epidermal growth factor receptor) inhibitors

The following non-prescription treatment has been tried with reports of success, but no formal studies have been done.

  • Tumeric, Passion Flower (1/10 of tumeric in effectiveness)
    • Less or no effect: gingko, black cohosh, echinacea, kava-kava, saw palmetto, angelica, wild yam, cat's claw, muira puama, feverfew, blueberry, chasteberry, licorice, nettle, golden seal, pygeum, ginger, valerian and hops.


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