R-Lipoic Acid
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R-Lipoic Acid is a new product [ only 16 Medline citations ]. It is related to Alpha-Lipoic Acid and appear to have more impact for some PWC's than ALA.

  • R-lipoic acid supplementation improves indices of metabolic activity as well as lowers oxidative stress and damage evident in aging.
  • R-lipoic acid (30 mg/kg) prevented hyperglycemia, reduced insulin levels, and increased free radical scavenging potential.
  •  a glucose (and lactate) lowering effect of R-lipoic acid in diabetic subjects.
  • R-lipoic acid acts to prevent depletion of GSH content and preserves the mitochondrial complex I activity which normally is impaired as a consequence of GSH loss.
  • "that the age-related decay of mitochondrial function can be partially reversed in older animals following treatment with R-lipoic acid or a combination of R-lipoic acid and acetyl-L-carnitine. In their study, older rats receiving either R-lipoic acid or a combination of R-lipoic acid and acetyl-L-carnitine showed signs of reduced lipid peroxidation and improved "
  • From LEF.org:
    Alpha lipoic acid contains 50% “R”-lipoic and 50% “S”-lipoic acids. While the body can utilize both forms of lipoic acid, the R-lipoic form is far more biologically active. For example, the “R”-form improves ATP synthesis in isolated cells, whereas the “S”-lipoic form does not. The R-lipoic acid form was shown to increase cell membrane fluidity and transport.

    As the biologically active form of the key “mitochondrial antioxidant” known as “alpha lipoic acid,” R-lipoic acid is directly involved in cellular metabolism. It is a vital component of the intracellular antioxidant cycle, able to scavenge a variety of free radicals and reactive oxygen species while recycling vitamins C, E and glutathione.

    “R”-lipoic acid readily crosses the blood brain barrier and has been shown effective for elevating intracellular glutathione levels. This biologically active lipoic acid isomer helps regulate neuronal calcium homeostasis, regulates pro-inflammatory cytokines, and alters the expression of ‘toxic genes.’ “R”-lipoic acid has been used to protect against adverse glucose reactions in the body and recommended as a ‘neuroprotective agent.’ Because “R”-lipoic is the naturally occurring form found in mitochondrial complexes, it offers substantially greater benefits at significantly lower doses than the synthetic forms of lipoic acid currently available.


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